Research Notes
Evidence-graded articles on canker sore science. Every factual claim is cited.
Strong EvidenceJan 25, 2024
Canker Sore vs. Cold Sore — How to Tell Them Apart
Canker sores and cold sores are completely different conditions — one is immune-mediated, the other is viral. Here's how to tell them apart clinically and why the treatment difference matters.
Read →Moderate EvidenceJan 22, 2024
Vitamin B12 Deficiency and Canker Sores — The RCT Evidence
A placebo-controlled RCT found 1000mcg sublingual B12 nightly reduced canker sore frequency regardless of baseline B12 levels. Here's the mechanism and what it means for chronic sufferers.
Read →Moderate EvidenceJan 20, 2024
SLS-Free Toothpaste and Canker Sores — What the RCT Actually Showed
A 1994 double-blind crossover RCT found that switching from SLS to SLS-free toothpaste reduced aphthous ulcer frequency by ~50%. Here's what the study showed and why the mechanism makes sense.
Read →